ABSTRACT
OBJECTIVE: To survey the role of Helicobacter pylori at the tissue level as a cause of squamous cell carcinoma of the larynx. DESIGN: A case-control study. SETTING: In an Otolaryngology Ward at an academic university. SUBJECTS: Patients with laryngeal cancer as cases and patients with benign laryngeal lesion as controls. MAIN OUTCOME MEASURE: In all subjects, specimens of laryngeal tissue were examined by rapid urease test while histopathologic examination was achieved to detect H. Pylori. RESULTS: Totally, 44 patients (42 men and 2 women) with squamous cell carcinoma of larynx and 30 patients (24 men and 6 women) with benign laryngeal lesions (polyp, nodule, granuloma) were studied, none of which were infected with the bacterium. CONCLUSION: Our results did not show H. Pylori infection among patients with laryngeal cancer (SCC) or benign laryngeal lesions. .
Subject(s)
Adult , Aged , Aged, 80 and over , Carcinoma, Squamous Cell/microbiology , Case-Control Studies , Female , Helicobacter Infections/microbiology , Helicobacter pylori/isolation & purification , Humans , Laryngeal Neoplasms/microbiology , Male , Middle Aged , Urease/metabolismABSTRACT
To evaluate a technique for Closure of large Septal Perforation [SP] by Split- Thickness Skin Graft and Cartilage. In this prospective study carried out from March 2000 to March 2005, 15 patients with large SP [>/= 2[cm2]] underwent closure of SP with split thickness skin graft and cartilage. The most common symptoms were nasal obstruction [66.7%] and crusts [46.7%]. In our technique, the success rate of closure was 86.7%. In two patients, closure was incomplete which was thought to be due their old age and long duration of SP. Our technique is easy, with good exposure, high success rate and is low in cost. We recommend this technique for perforation >/= 2[cm2]